ABNORMAL OCULAR MOVEMENTS IN PARKINSON'S DISEASE
Identifieur interne : 002812 ( Main/Exploration ); précédent : 002811; suivant : 002813ABNORMAL OCULAR MOVEMENTS IN PARKINSON'S DISEASE
Auteurs : Olivier Rascol [France] ; M. Clanet [France] ; J. L. Montastruc [France] ; M. Simonetta [France] ; M. J. Soulier-Esteve [France] ; B. Doyon [France] ; A. Rascol [France]Source :
- Brain [ 0006-8950 ] ; 1989-10.
Abstract
Quantitated automated electro-oculographic data from 45 parkinsonian patients were compared with those from 30 normal control subjects. Patients were selected with idiopathic Parkinson's disease without other associated neurological disease or dementia; 20 had never received antiparkinsonian drugs and in 25 such treatment had been stopped for at least 2 days. Saccade latency, amplitude and peak velocity, smooth pursuit peak velocity, optokinetic nystagmus (OKN) maximal and mean velocities and vestibulo-ocular reflex (VOR) suppression by vision or imagination were significantly altered in patients, whereas VOR gain in darkness was normal. Alterations of saccade latency and smooth pursuit peak velocity were more severe in the more advanced stages of the disease and saccade latency directed towards the symptomatic side was slightly delayed in hemiparkinsonian patients. Saccade amplitude improved 90 min after a single oral dose of L-DOPA. These results suggest a possible dopaminergic control of some ocular movements.
Url:
DOI: 10.1093/brain/112.5.1193
Affiliations:
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Patients were selected with idiopathic Parkinson's disease without other associated neurological disease or dementia; 20 had never received antiparkinsonian drugs and in 25 such treatment had been stopped for at least 2 days. Saccade latency, amplitude and peak velocity, smooth pursuit peak velocity, optokinetic nystagmus (OKN) maximal and mean velocities and vestibulo-ocular reflex (VOR) suppression by vision or imagination were significantly altered in patients, whereas VOR gain in darkness was normal. Alterations of saccade latency and smooth pursuit peak velocity were more severe in the more advanced stages of the disease and saccade latency directed towards the symptomatic side was slightly delayed in hemiparkinsonian patients. Saccade amplitude improved 90 min after a single oral dose of L-DOPA. These results suggest a possible dopaminergic control of some ocular movements.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li></region><settlement><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li><li>Université de Toulouse</li></orgName></list><tree><country name="France"><region name="Midi-Pyrénées"><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">Olivier Rascol</name></region><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M." last="Clanet">M. Clanet</name><name sortKey="Clanet, M" sort="Clanet, M" uniqKey="Clanet M" first="M." last="Clanet">M. Clanet</name><name sortKey="Doyon, B" sort="Doyon, B" uniqKey="Doyon B" first="B." last="Doyon">B. Doyon</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J. L." last="Montastruc">J. L. Montastruc</name><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">Olivier Rascol</name><name sortKey="Simonetta, M" sort="Simonetta, M" uniqKey="Simonetta M" first="M." last="Simonetta">M. Simonetta</name><name sortKey="Simonetta, M" sort="Simonetta, M" uniqKey="Simonetta M" first="M." last="Simonetta">M. Simonetta</name><name sortKey="Soulier Esteve, M J" sort="Soulier Esteve, M J" uniqKey="Soulier Esteve M" first="M. J." last="Soulier-Esteve">M. J. Soulier-Esteve</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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